Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
T Montecchi, G Nannini, D De Tommaso… - Cancer Immunology …, 2024 - Springer
… protein Rai is a negative regulator of T cell receptor signaling … hyperactive phenotype of T
cells in autoimmune diseases. … suppresses TCR signaling and T cell activation, together with …
cells in autoimmune diseases. … suppresses TCR signaling and T cell activation, together with …
[HTML][HTML] AT cell suppressive circuitry mediated by CD39 and regulated by ShcC/Rai is induced in astrocytes by encephalitogenic T cells
C Ulivieri, D De Tommaso, F Finetti, B Ortensi… - Frontiers in …, 2019 - frontiersin.org
… in the mouse experimental autoimmune encephalomyelitis (EAE… identify Rai as a negative
regulator of this inhibitory circuitry. … in T cells Rai limits antigen receptor signaling by impairing …
regulator of this inhibitory circuitry. … in T cells Rai limits antigen receptor signaling by impairing …
The Yin and Yang of myeloid derived suppressor cells
… activity of inhibiting antigen dependent T cell activation (8). … Known to act solely as negative
regulators of immune system, … the risk of autoimmune diseases, blocking of MDSCs based …
regulators of immune system, … the risk of autoimmune diseases, blocking of MDSCs based …
Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions
… negative regulators of G protein function and RhoG. ARHGDIG or Rho-GDP-dissociation
inhibitor-3 inhibits … against immunological disorders such as autoimmune diseases and other …
inhibitor-3 inhibits … against immunological disorders such as autoimmune diseases and other …
The adaptor protein Rai/ShcC promotes astrocyte-dependent inflammation during experimental autoimmune encephalomyelitis
C Ulivieri, MT Savino, I Luccarini… - The Journal of …, 2016 - journals.aai.org
… associated with spontaneous T and B cell activation, and crescential … Rai, which we have
identified as a negative regulator of TCR … antagonizes Th17 cell development and inhibits their …
identified as a negative regulator of TCR … antagonizes Th17 cell development and inhibits their …
Chronic lymphocytic leukaemia
…, WG Wierda, S O'brien, J Gribben, K Rai - Nature reviews Disease …, 2017 - nature.com
… –ERK pathway indicates negative regulation. *For more … of the surface antigen receptors in
the absence of adequate T cell help. … of an autoimmune cytopenia (for example, autoimmune …
the absence of adequate T cell help. … of an autoimmune cytopenia (for example, autoimmune …
Molecular characterization of the differential outcome of Rai modulation in astrocytes and T lymphocytes leading to context-specific cellular dysfunction
T Montecchi - 2023 - usiena-air.unisi.it
… activity of Rai as a negative regulator of TCR and BCR signaling, it has been observed that
… differentiation and autoimmunity The ability of Rai to fine-tune the antigen receptor signaling …
… differentiation and autoimmunity The ability of Rai to fine-tune the antigen receptor signaling …
The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity
A Gonzalez-Martin, BD Adams, M Lai, J Shepherd… - Nature …, 2016 - nature.com
… impaired B cell tolerance by promoting the survival of immature B cells after engagement
of the B cell antigen receptor by suppressing the expression of the autoimmune suppressor …
of the B cell antigen receptor by suppressing the expression of the autoimmune suppressor …
FcγRIIb expression in early stage chronic lymphocytic leukemia
…, S Jansà, R Damle, S Gorlatov, K Rai… - Leukemia & …, 2017 - Taylor & Francis
… -cell antigen receptor (BCR) signaling can be negatively … negative regulator of BCR signaling
has been extensively studied in normal B-cells [Citation15–21] and in human autoimmune …
has been extensively studied in normal B-cells [Citation15–21] and in human autoimmune …
[HTML][HTML] Lysophosphatidic acid is an inflammatory lipid exploited by cancers for immune evasion via mechanisms similar and distinct from CTLA-4 and PD-1
… against self-antigens and prevent autoimmunity. One … PD-1 in inhibiting T cell antigen
receptor (TCR) signaling, yet via distinct … Given the negative regulation of CD8 T cells by an LPA-…
receptor (TCR) signaling, yet via distinct … Given the negative regulation of CD8 T cells by an LPA-…